1ireNews ................................Dem......Saginaw t ........3,850 SCHO0LCRASaginawian .......................Dem..... ........ 750Saginaw Post (Ger.) .........Ind ..... " .........4,733 Dem. vote in 1892,SaginawSonntagsblatt(Ger.)......... " ......... Hilly and brokenSaginaw Zeitung - see Ind ducts-Grain and p(Saginaw Sonntagsblatt . "*" ..... bering chiefindustryValley News ....................Rep ..... " ......... 650 2,940.W orld ........................................ .......... Frem ad (Nor-Dan.)World " ..... ... Fremad (Nor-Dan.)Independent .....................Ind......St. Charles ........ 1,000 News........................Pioneer (s-wkly) ....ST. CLAIR CO. (E.) ..............Pop. 52,105 Tribune ..................Rep. vote in 1888, 5,371; Dem. 5,248; Pro. 288; Peo. 81.Undulating; extensive forests; soil fertile. Pro- AWASducts-Oats, wheat, corn, potatoes, butter, wool, hay,hops; live stock. Salt has recently been discovered in p vote in 1892 3,immense beds and is being worked. Manufactures are epextensive; many breweries. COUNTY SEAT, Port Nearly level; soiHuron, pop. 13,543. mined extensively.Cir barley, potatoes, buAdvance ............................Ind .....Algonac............ stock. ManufacturJournal .............................Local...Capac ............... 600 1,382.Sun ...................................Ind......Fort Gratiot....... 840 CommercialThreshermen's Review Trade " Herald ...................(monthly) ..................IMagnet .............................Dem.....Marine City ...... 725 Independent...........Reporter ....................Ind.Rep ........ ...... 650 Journal........Bee Hive (mo) ............K.O.T.M...Port Huron t..54,000 ess and InterHerald ..............................Dem ..... News.......................H erold (Ger.)....................Dem ..... ...... 1,200 ribune .................Michigan Maccabee (mo.)K. of Mac. " .....54,00 Evening Argus (evNews (evg.) ................................... Odd Fellow (s-mo.)News ............................................. Press.......................Sunday Herald .................Dem.... " ...... 1,560 Shiawassee AmericTimes (evg.) ....................Rep ..... ......2,250 Shiawassee Co. RepTim es ..............................Rep ......... 2,050 Tim es.............. .......Tribune.......................Ind.Dem .... ......2,20 Shiawassee Co. LibRepublican .......................Rep .....St. Clair ............*1,161 Argus .....................Expositor ......................... Rep .....Yale.................. 900TUSCOLA COST. JOSEPH CO. (S.) ...........Pop. 25,356 Rep. vote in 1892,3,Rep. vote in 1888, 2,824; Dem. 2,441; Peo. 978; Pro. 185. Nearly level; tilUndulating; large forests; soil fertile. Products- ducts--heat, oats,Wheat and corn large; oats, potatoes, peppermint, live stock. Lumbe:butter, wool, hay, sorghum molasses, pork; live stock. Caro, pop. 1,701.Manufactures - Breweries, ship yards, etc. COUNTYSEAT, Centerville, pop. 775. Democrat...............CireAcorn ....................... ......Local...Burr Oak........... 700 Home Life (mo.)Observer .......................... Rep .....Centerville t...... 600Express ...........................Ind......Colon................. *616 EnterpriseSt:Joseph Co. Advertiser..Rep .....Constantine ...... 1,032 Montor-SayigsGlobe .................................In d ........... '960 eiCrescent..................Cooper's Coffee Cooler G.A.R.SSturgis..........5.00 Times.....................(monthly) .................. } .A....tri... 4Journal-for sub-edition, Rep R............ scola ontsee Catalogue................ p 1,060Michigan Democrat .........Dem..... ..............*1,400 VAN BUTim es ..............................D em ..... ..............Herald .............................Dem.....Three Rivers.....*1,030 Rep. vote in 1892, 3,Press (evg.) .......................Ind ..... " ..... Nearlylevel; sovNearly level; soiSt. Joseph Co. Sentinel.....Pop ..... Corn, wheat, oats,Tribune ................ ep .. " .....*1.128 hay in large quLarge manufactur!Journal .............................Rep .....White Pigeon ... t920 1,t91.SANILAC CO. (E.) .................Pop. 32,59 Advance................Rep. vote in 1888, 2,994; Dem. 1,730; Peo. 78. Breeze ...................Undulating; soil fertile. Products - Wheat, oats, Leader.....potatoes, butter, wool, hay, maple sugar; live stock. VanBuren Co.RepuLarge manufacturing interests. COUNTY SEAT, San- News .....................ilac Centre, pop. 403. CJire Day Spring.............Banner..............................Ind .....Brown City ...... f600 People's Alliance..County Journal.................Rep .....Carsonville ...... Leader...................Democrat ...................... ...Croswell ............850 Free Press and CoSanilac Jeffersonian .........Rep .....Lexington......... 1,250 True Northerner....Leader .............................Ind......M arlette............1,104 Leaflet (mo.).........Herald ..............................Dem.....Minden City ..... 288 Messenger .............Sanilac Co. Republican.....Rep .....Sanilac Centre ttl,450 Sentinel.................CIRCULATION; Publishers' reports. Roman figures-estimated. * Sworn.POPULATION: Census of 1890. *Estimated. t County Seat.
Episode 1.128
Bipolar affective disorder (BD) refers to periodic changes in mood and activity from depression to mania. It affects 1 % of population. Two types of disorder (type I and type II) are distinguished by severity of mania episodes [10]. Mixed states are also observed. Psychotic symptoms are observed in some cases [11]. Family history of bipolar disorder is important risk factor [12]. As in schizophrenia, environmental risk factors of disorder are known. Dysfunctional interactions among family members increase the risk [13].
We saw relation between premorbid personality disorders and depression domain. Important aspect of depression in schizophrenia, is possible difficulty to distinguish from negative symptoms [47], which are typically present [48]. Premorbid personal disorders, depressive and negative manifestations might exhibit similar clinical picture. Apathy and lack of emotion are similar in both depressive and negative manifestations [49]. Depressive symptoms may be present in chronic phase and acute schizophrenia episode [34]. The fact that OPCRIT items describing premorbid social functioning increases severity of depressive manifestations only, might be results of difficulty mentioned. Early age at onset is associated with more severe negative symptoms of schizophrenia as [50] suggested. We saw late age at onset being protective towards depressive symptoms. However depressive and negative symptoms partly overlap in schizophrenia [51].
Statistical methods enable researchers to detect and describe relationships. Pandina group applied regression models to analyse clinical symptoms and demographic characteristics influences cognitive improvement in schizophrenia and schizoaffective disorder [58]. Fiedorowicz group proved family history of bipolar disorders influence illness course, by increasing risk of hypomania/mania episodes frequency [59]. Recently Skokou and Gourzis checked how age at onset, sex, habitat, marital status and premorbid personality disorders influence paranoid schizophrenia. They proved urban birth, single status and avoidant personality traits are observed in young patients. Differences were more significant in male group. [60]. Detailed analyses of premorbid personality disorders and familial burden is needed to introduce more detailed models.
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